Toxicities of aristolochic acid I and aristololactam I in cultured renal epithelial cells.

@article{Li2010ToxicitiesOA,
  title={Toxicities of aristolochic acid I and aristololactam I in cultured renal epithelial cells.},
  author={Ji Li and Liang Zhang and Zhen-zhou Jiang and Bin Shu and Fu Li and Qingli Bao and Lu-yong Zhang},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2010},
  volume={24 4},
  pages={1092-7}
}
Aristolochic acid nephropathy, a progressive tubulointerstitial renal disease, is primarily caused by aristolochic acid I (AA-I) intoxication. Aristololactam I (AL-I), the main metabolite of AA-I, may also participate in the processes that lead to renal damage. To investigate the role and mechanism of the AL-I-mediated cytotoxicity, we determined and compared the cytotoxic effects of AA-I and AL-I on cells of the human proximal tubular epithelial (HK-2) cell line. To this end, we treated HK-2… CONTINUE READING

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