Toxicities of aristolochic acid I and aristololactam I in cultured renal epithelial cells.

  title={Toxicities of aristolochic acid I and aristololactam I in cultured renal epithelial cells.},
  author={Ji Li and Liang Zhang and Zhen-zhou Jiang and Bin Shu and Fu Li and Qingli Bao and Lu-yong Zhang},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  volume={24 4},
Aristolochic acid nephropathy, a progressive tubulointerstitial renal disease, is primarily caused by aristolochic acid I (AA-I) intoxication. Aristololactam I (AL-I), the main metabolite of AA-I, may also participate in the processes that lead to renal damage. To investigate the role and mechanism of the AL-I-mediated cytotoxicity, we determined and compared the cytotoxic effects of AA-I and AL-I on cells of the human proximal tubular epithelial (HK-2) cell line. To this end, we treated HK-2… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 15 extracted citations


Publications referenced by this paper.
Showing 1-10 of 15 references

Induction of urothelial proliferation in rats by aristolochic acid through cell cycle progression via activation of cyclin D1/cdk4 and cyclin E/cdk2.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association • 2006
View 1 Excerpt

Apoptotic signal transduction: emerging pathways.

Biochemistry and cell biology = Biochimie et biologie cellulaire • 1998
View 1 Excerpt

Caspases: killer proteases.

Trends in biochemical sciences • 1997
View 1 Excerpt

Similar Papers

Loading similar papers…