Toxicant-induced ER-stress and caspase activation in the olfactory mucosa

  title={Toxicant-induced ER-stress and caspase activation in the olfactory mucosa},
  author={Anna Franz{\'e}n and Eva B. Brittebo},
  journal={Archives of Toxicology},
The potent olfactory toxicant 2,6-dichlorophenyl methylsulphone (2,6-diClPh-MeSO2) induces rapid cell death and long-term metaplastic changes in the olfactory regions of rodents. The damage is related to a tissue-specific and extensive cytochrome P450 (CYP)-mediated metabolic activation of the compound to reactive intermediates. The aim of the present study was to examine the early, cell-specific changes leading to cell death in the olfactory mucosa of mice exposed to 2,6-diClPh-MeSO2. We have… CONTINUE READING
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Pathology of the olfactory mucosa: implications for the treatment of olfactory dysfunction

  • RC Kern, DB Conley, GK 3rdHaines, AM Robinson
  • Laryngoscope
  • 2004
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