Toxic proteins released from mitochondria in cell death

@article{Saelens2004ToxicPR,
  title={Toxic proteins released from mitochondria in cell death},
  author={Xavier Saelens and Nele Festjens and Lieselotte Vande Walle and Maria van Gurp and G. C. van Loo and Peter Vandenabeele},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={2861-2874}
}
A plethora of apoptotic stimuli converge on the mitochondria and affect their membrane integrity. As a consequence, multiple death-promoting factors residing in the mitochondrial intermembrane space are liberated in the cytosol. Pro- and antiapoptotic Bcl-2 family proteins control the release of these mitochondrial proteins by inducing or preventing permeabilization of the outer mitochondrial membrane. Once released into the cytosol, these mitochondrial proteins activate both caspase-dependent… CONTINUE READING
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