Toxic phorbol esters from Chinese tallow stimulate protein kinase C.

@article{Brooks1987ToxicPE,
  title={Toxic phorbol esters from Chinese tallow stimulate protein kinase C.},
  author={Gavin Brooks and Nicholas A. Morrice and Christopher Ellis and Alastair Aitken and A. Thomas Evans and Fred J. Evans},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={1987},
  volume={25 11},
  pages={1229-33}
}
Phorbol esters were isolated from the seeds of Chinese tallow (Sapium sebiferum L. Roxb.). These compounds were based on the tigliane nuclei, 4-deoxyphorbol, 12-deoxyphorbol and 4,20-dideoxy-5-hydroxyphorbol. The pro-inflammatory activity (ID50) of the pure compounds was between 0.042 and 2.6 nmoles per ear. Protein kinase C activation assays were carried out on samples of enzyme purified from mammalian brain and the activities (Ka) were in the range 76-176 nM. The 4,20-dideoxy-5-hydroxy… CONTINUE READING
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