Toxic oxygen: The radical life-giver

  title={Toxic oxygen: The radical life-giver},
  author={Doris Abele},
  • D. Abele
  • Published 7 November 2002
  • Medicine, Chemistry
  • Nature
A primary function of mitochondria may have been to compartmentalize respiration, thus protecting cells from the damaging side-effects of oxygen metabolism. 
Oxygen-induced reperfusion-injury is caused by ROS: Amelioration is possible by recombinant-DNA antioxidant enzymes and mimics in selected tissues.
  • A. Wiseman
  • Chemistry, Medicine
  • Medical hypotheses
  • 2006
O2 itself will be recognised universally as a harmful gas that can subject the cell to oxidative stress; because it produces ROS, such as the superoxide anion when it acts as the terminal electron acceptor in cellular respiration in the production of water from hydrogen ions in mitochondria. Expand
Oxidative damage and carcinogenesis
Oxygen is an essential element to conduct life processes but some of the metabolic byproducts e.g. reactive oxygen species, are toxic for living organisms and ROS are considered as a significant class of carcinogens participating in cancer initiation, promotion and progression. Expand
Formation of reactive species and induction of antioxidant defence systems in polar and temperate marine invertebrates and fish.
  • D. Abele, S. Puntarulo
  • Biology, Medicine
  • Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
  • 2004
This review summarizes current knowledge on pro- and antioxidant processes in marine invertebrates and fish, and relates reactive oxygen species (ROS) formation in polar ectotherms to homeoviscous adaptations of membrane and storage lipids, as well as to tissue hypoxia and re-oxygenation during physiological stress. Expand
Marine invertebrate mitochondria and oxidative stress.
A new concept is proposed, showing how the cross talk of reactive O2 species in metabolically low marine invertebrates could support their outstanding hypoxia tolerance under non-stressed conditions. Expand
A Modulating Role for Antioxidants in Desiccation Tolerance1
The failure of the antioxidant system during long-term desiccation appears to trigger programmed cell death, causing ageing and eventual death of the organism, which suggests that a potent antioxidant machinery is one of the underlying mechanisms of Desiccation tolerance. Expand
Oxidative Stress, Diabetes, and Its Complications
In fact, even being scarcely reactive this molecule has the tendency to ‘radicalize,’ forming incompletely reduced molecules characterized by an uncoupled electron. This highly reactive andExpand
Role of redox metabolism for adaptation of aquatic animals to drastic changes in oxygen availability.
A novel explanation for the biochemical and molecular mechanisms involved in this phenomenon that could be triggered by hypoxia-induced ROS formation is proposed and the connections among oxygen sensing, oxidative damage and regulation of the endogenous antioxidant defense apparatus in animals adapted to many natural or man-made challenges of the aquatic environment are discussed. Expand
Novel cytochromes P450 applications arising from the directed‐evolution of recombinant micro‐organisms
  • A. Wiseman
  • Biology, Medicine
  • Letters in applied microbiology
  • 2003
Directed (forced) evolution of cytochromes P450 (overall 2700 CYP isoforms in non‐recombinant biota) is a method that has been investigated in yeasts by aerobically growing brewers’ yeast Saccharomyces cerevisiae in very high glucose (20%) media. Expand
Oxidative Stress in Human Pathology
The nature of the mediators of oxidative stress, their source and their biological targets are explained in some detail, allowing the reader to understand the link between a defined environmental condition and its biological consequences involving a cascade of undesirable non-specific oxidations when the endogenous antioxidant defences are saturated. Expand
Thermal tolerance and thermal sensitivity of heart mitochondria: Mitochondrial integrity and ROS production.
The results show that, at temperatures close to the thermal limit, mitochondrial capacity is compromised and ROS production rates increase, underlining the important role that mitochondria play in setting thermal tolerance limits. Expand