Toxic neuronal apoptosis and modifications of tau and APP gene and protein expressions.

@article{Hugon1999ToxicNA,
  title={Toxic neuronal apoptosis and modifications of tau and APP gene and protein expressions.},
  author={Jacques Hugon and Françoise Esclaire and Mathieu J Lesort and Glen E. Kisby and Pamela Spencer},
  journal={Drug metabolism reviews},
  year={1999},
  volume={31 3},
  pages={635-47}
}
The causes and the mechanisms of neuronal death in Alzheimer's disease are not elucidated, although some new insights have been proposed over the past years, including free-radical toxicity, beta-amyloid toxicity, excitotoxicity, and disturbed cellular calcium metabolism. Some authors have also pointed out that apoptosis could play a role in neuronal degeneration, but it is still largely debated. Here, we review some recent data linking the induction of experimental neuronal apoptosis in vitro… CONTINUE READING
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