Toxic lifespan of the synthetic opioid U-47,700 in Finland verified by re-analysis of UPLC-TOF-MS data.

@article{Kriikku2019ToxicLO,
  title={Toxic lifespan of the synthetic opioid U-47,700 in Finland verified by re-analysis of UPLC-TOF-MS data.},
  author={Pirkko Kriikku and Anna Pelander and Ilpo Rasanen and Ilkka Ojanper{\"a}},
  journal={Forensic science international},
  year={2019},
  volume={300},
  pages={
          85-88
        }
}

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References

SHOWING 1-10 OF 28 REFERENCES

Quantification of U-47700 and its metabolites in plasma by LC-MS/MS.

A Fatality Related to the Synthetic Opioid U-47700: Postmortem Concentration Distribution.

TLDR
An evaluation of the distribution of postmortem concentrations of 3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide (U-47700) in a fatality attributed principally to the drug is presented.

Analysis of Novel Synthetic Opioids U-47700, U-50488 and Furanyl Fentanyl by LC-MS/MS in Postmortem Casework.

TLDR
Given the widespread geographical distribution and increase in prevalence in postmortem casework, toxicology testing should be expanded to include testing for "designer opioids" in cases with histories consistent with opioid overdose but with no traditional opioids present or insufficient quantities to account for death.

A case of U-47700 overdose with laboratory confirmation and metabolite identification

TLDR
U-47700 is a potent μ-opioid receptor agonist and has recently been used recreationally, contributing to hospitalizations and likely deaths in the community and appears to be an appropriate marker of use in a serum sample.

Two cases of intoxication with new synthetic opioid, U-47700

TLDR
Two patients presenting after insufflation of U-47700, a relatively new agent that is easy to obtain over the internet and has the potential to cause significant morbidity and mortality are reported.

Postmortem concentration distribution in fatal cases involving the synthetic opioid U-47700

TLDR
The data concerning U-47700 concentration distribution in postmortem specimens collected after two lethal intoxications showed femoral blood concentrations were lower than the urine/heart blood concentrations and can be defined as high when compared with toxic morphine levels, well known that the interpretation of postmortem drug concentration is a big challenge.

Quantification of U-47700 and its metabolites: N-desmethyl-U-47700 and N,N-didesmethyl-U-47700 in 12 autopsy blood samples employing SPE/LC–ESI-MS-MS

PurposeThe paper presents a report on the comprehensive assessment of a novel synthetic opioid (NSO) termed U-47700, and its two metabolites: N-desmethyl-U-47700 and N,N-didesmethyl-U-47700 in

Near death from a novel synthetic opioid labeled U-47700: emergence of a new opioid class

TLDR
A patient who suffered respiratory failure and depressed level of consciousness after recreationally using a novel synthetic opioid labeled U-47700 was treated with naloxone, which completely reversed his opioid poisoning.

A Case Study Involving U-47700, Diclazepam and Flubromazepam-Application of Retrospective Analysis of HRMS Data.

TLDR
The coronial case reported here illustrates the application of retrospective processing of HRMS data in the detection of emerging NPS, revealing the presence of designer benzodiazepines, diclazepam and flubromazep am as well as the psychedelic drug 2,5-dimethoxy-4-chloroamphetamine.