Toxic interactions of ethanol with other central depressants: Antagonism by naloxone to narcosis and lethality

@article{Ho1979ToxicIO,
  title={Toxic interactions of ethanol with other central depressants: Antagonism by naloxone to narcosis and lethality},
  author={Andrew K. S. Ho and Chiu C. Ho},
  journal={Pharmacology Biochemistry and Behavior},
  year={1979},
  volume={11},
  pages={111-114}
}
  • A. Ho, C. Ho
  • Published 1 July 1979
  • Medicine, Chemistry
  • Pharmacology Biochemistry and Behavior
The effects of naloxone on narcosis and/or lethality induced by diazepam, lithium, methaqualone and phenobarbital either alone or in combination with ethanol were studied in mice. Interaction toxicities between ethanol and the various psychotropic drugs were dose-dependent and so was the degree of antagonism by naloxone. Treatment with phenobarbital (10 mg/kg) or methaqualone (50 mg/kg) or lithium (4 meq/kg) prolonged the narcosis induced by ethanol (5 g/kg) by 45, 269 and 107% respectively… 
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  • M. Kreek
  • Medicine
    Annals of the New York Academy of Sciences
  • 1981
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There was no suggestion of ethanol impairment being moderated by naloxone, whether it was given before or after ethanol, and there were no significant differences in either blood or breath ethanol concentrations at any time between the ethanol + naloxin and ethanol + saline groups in either Experiment 1 or 2.
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It is indicated that naloxone can alter the effects of chronic ethanol exposure and further suggest that ethanol may exert some of its actions via the brain opioid system.
Effects of ethanol and naltrexone on free-operant avoidance behavior in rats
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The results provided little support for the hypothesis that the effects of ethanol on avoidance performance are mediated by the opiate receptor system, and instead provided evidence of heightened sensitivity to ethanol.
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  • A. Ho, C. C. Ho
  • Chemistry, Medicine
    Alcoholism, clinical and experimental research
  • 1978
TLDR
Retention of lithium induced by ethanol appeared to be responsible for the potentiation of lithium toxicity and the potential hazard in the interaction between lithium and ethanol is discussed.
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