Toxic interactions of ethanol with other central depressants: Antagonism by naloxone to narcosis and lethality

@article{Ho1979ToxicIO,
  title={Toxic interactions of ethanol with other central depressants: Antagonism by naloxone to narcosis and lethality},
  author={A. Ho and C. Ho},
  journal={Pharmacology Biochemistry and Behavior},
  year={1979},
  volume={11},
  pages={111-114}
}
  • A. Ho, C. Ho
  • Published 1979
  • Medicine, Chemistry
  • Pharmacology Biochemistry and Behavior
The effects of naloxone on narcosis and/or lethality induced by diazepam, lithium, methaqualone and phenobarbital either alone or in combination with ethanol were studied in mice. Interaction toxicities between ethanol and the various psychotropic drugs were dose-dependent and so was the degree of antagonism by naloxone. Treatment with phenobarbital (10 mg/kg) or methaqualone (50 mg/kg) or lithium (4 meq/kg) prolonged the narcosis induced by ethanol (5 g/kg) by 45, 269 and 107% respectively… Expand
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  • M. Kreek
  • Medicine
  • Annals of the New York Academy of Sciences
  • 1981
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  • Chemistry, Medicine
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