Toxic fibrillar oligomers of amyloid-β have cross-β structure.

@article{Stroud2012ToxicFO,
  title={Toxic fibrillar oligomers of amyloid-β have cross-β structure.},
  author={James C. Stroud and Chang’E. Liu and Poh K Teng and David S. Eisenberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 20},
  pages={
          7717-22
        }
}
Although amyloid fibers are found in neurodegenerative diseases, evidence points to soluble oligomers of amyloid-forming proteins as the cytotoxic species. Here, we establish that our preparation of toxic amyloid-β(1-42) (Abeta42) fibrillar oligomers (TABFOs) shares with mature amyloid fibrils the cross-β structure, in which adjacent β-sheets adhere by interpenetration of protein side chains. We study the structure and properties of TABFOs by powder X-ray diffraction, EM, circular dichroism… CONTINUE READING

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