Toxic epidermal necrolysis caused by cetuximab plus minocycline in head and neck cancer.

@article{Lee2010ToxicEN,
  title={Toxic epidermal necrolysis caused by cetuximab plus minocycline in head and neck cancer.},
  author={S Y Lee and P F Chu},
  journal={American journal of otolaryngology},
  year={2010},
  volume={31 4},
  pages={288-90}
}
We present a unique case of toxic epidermal necrolysis (TEN) caused by cetuximab plus minocycline during chemoradiation for recurrent squamous cell carcinoma of the head and neck (SCCHN). In April 2008, a 49-year-old man was diagnosed with recurrent SCCHN. He received surgery and postoperative adjuvant therapy with cetuximab plus chemoradiation. Because of exacerbation of acneform rash by cetuximab, minocycline was added thereafter. However, TEN appeared after the fifth course of weekly… CONTINUE READING

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