Toxic epidermal necrolysis and Stevens-Johnson syndrome: does early withdrawal of causative drugs decrease the risk of death?

  title={Toxic epidermal necrolysis and Stevens-Johnson syndrome: does early withdrawal of causative drugs decrease the risk of death?},
  author={Ignacio Garc{\'i}a-Doval and L Lecleach and H{\'e}l{\`e}ne Bocquet and X L Otero and Jean Claude Roujeau},
  journal={Archives of dermatology},
  volume={136 3},
BACKGROUND Withdrawal of the drug(s) that cause severe cutaneous adverse reactions is usually recommended without proof that it alters the course of those reactions. OBJECTIVE To determine whether the timing of causative drug withdrawal is related to the prognosis of patients with toxic epidermal necrolysis (TEN) or Stevens-Johnson syndrome (SJS). DESIGN A 10-year observational study (January 1, 1987, through October 30, 1997) of patients admitted to a dermatological intensive care unit… 

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