Toxic effects of midazolam on differentiating neurons in vitro as a consequence of suppressed neuronal Ca2+-oscillations.

@article{Sinner2011ToxicEO,
  title={Toxic effects of midazolam on differentiating neurons in vitro as a consequence of suppressed neuronal Ca2+-oscillations.},
  author={Barbara Sinner and Oliver Friedrich and York Alexander Zausig and Thomas Bein and B. M. Graf},
  journal={Toxicology},
  year={2011},
  volume={290 1},
  pages={
          96-101
        }
}
BACKGROUND In immature neurons anesthetics induce apoptosis and influence neuronal differentiation. Neuronal Ca(2+)-oscillations regulate differentiation and synaptogenesis. We examined the effects of the long-term blockade of hippocampal Ca(2+)-oscillations with midazolam on neuronal synapsin expression. MATERIAL AND METHODS Hippocampal neurons were incubated at day 15 in culture with the specific GABA(A) receptor agonist muscimol (50μM) or with midazolam (100 and 300nM), respectively, for… CONTINUE READING
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