Toxic effects of microbial phenolic acids on the functions of mitochondria.

@article{Fedotcheva2008ToxicEO,
  title={Toxic effects of microbial phenolic acids on the functions of mitochondria.},
  author={Nadezhda I. Fedotcheva and R. Kazakov and Maria N. Kondrashova and Natalia V. Beloborodova},
  journal={Toxicology letters},
  year={2008},
  volume={180 3},
  pages={
          182-8
        }
}
Low-molecular-weight phenolic acids (PhAs) phenylacetate, phenyllactate, phenylpropionate, p-hydroxyphenyllactate, and p-hydroxyphenylacetate are essentially the products of the degradation of aromatic amino acids and polyphenols by the intestinal microflora. In sepsis, the concentrations of some of these acids in the blood increase tens of times. Assuming that these compounds can cause the mitochondrial dysfunction in sepsis, we examined their effects on respiration, the induction of pore… CONTINUE READING

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