• Corpus ID: 74434237

Toxic effects of metals

  title={Toxic effects of metals},
  author={Robert A. Goyer and Thomas W. Clarkson},
Essentiality Toxicity Carcinogenicity Lead(Pb) Exposure Toxicokinetics Toxicity Neurologic, Neurobehavioral, and Developmental Effects in Children Mechanisms of Effects on the Developing Nervous System Peripheral Neuropathy Hematologic Effects Renal Toxicity Lead and Gout Effects on Cardiovascular System Immunotoxicity Bone Effects Reproductive Effects Birth Outcomes Carcinogenicity Other Effects Dose Response Treatment Organic Lead Compounds Mercury (Hg) Exposure Disposition and Toxicokinetics… 

Nickel, its adverse health effects & oxidative stress.

A selective review on nickel and effect of its acute, subchronic and chronic doses on certain metabolically active tissues in human as well as animals is presented.

Cadmium, Lead, Thallium: Occurrence, Neurotoxicity and Histopathological Changes of the Nervous System

Neuropathology is frequently used to evaluate the effects of toxic agents on nervous system organization and cellular components; thus, careful histologic evaluations increase knowledge of the neurotoxicity of heavy metals.

Chemical and biological properties of toxic metals and use of chelating agents for the pharmacological treatment of metal poisoning

The present review attempts to provide updated information about the mechanisms, the cellular targets and the effects of toxic metals.

Dietary Strategies for the Treatment of Cadmium and Lead Toxicity

The evidence for protective effects of essential metals, vitamins, edible plants, phytochemicals, probiotics and other dietary supplements against Cd and Pb toxicity is reviewed and the proposed possible mechanisms are described.

The Speciation of Metals in Mammals Influences Their Toxicokinetics and Toxicodynamics and Therefore Human Health Risk Assessment

The influence of speciation on metal toxicokinetics and toxicodynamics in mammals, and therefore the adverse effects of metals, is reviewed to illustrate how the physicochemical characteristics of metals and their handling in the body (toxicokinetics) can influence toxicity (t toxicodynamics).

Heavy Metals Intoxication and Health Effects

Heavy metals are the hazardous substances that produced by industrial waste, included lead (Pb), mercury (Hg), kadnium (Cd), arsenic (As), copper (Cu), and chromium (Cr). Characteristics of lead (Pb)

Testing for Toxic Elements: A Focus on Arsenic, Cadmium, Lead, and Mercury

In this review, toxicokinetics and pre-analytical variables associated with toxic element testing are discussed, with emphasis on arsenic, cadmium, lead, and mercury.

Arsenic toxicity, mutagenesis, and carcinogenesis – a health risk assessment and management approach

A comprehensive analysis of published data indicates that arsenic exposure induces cardiovascular diseases, developmental abnormalities, neurologic and neurobehavioral disorders, diabetes, hearing



Cadmium and Health: A Toxicological and Epidemiological Appraisal

This book contains the following chapters: Respiratory Effects. Renal Effects. Effects on Bone, on Vitamin D, and Calcium Metabolism. Other Toxic Effects. Carcinogenic and Genetic Effects. Critical

Usefulness of biomarkers of exposure to inorganic mercury, lead, or cadmium in controlling occupational and environmental risks of nephrotoxicity.

Monitoring HgU is useful for controlling the nephrotoxic risk of overexposure to inorganic mercury; HGU should not exceed 50 micrograms Hg/g creatinine in order to prevent cytotoxic and functional renal effects.

Occupational and environmental chemical hazards: Cellular and biochemical indices for monitoring toxicity

This book deals with the tools applicable to the investigation of chemical toxicity in a variety of organs in the human host, and discusses of indices in current or proposed use for toxic effects on hepatic, renal, and nervous system functions in porphyrin metabolism.

Chromium-induced genotoxicity and apoptosis: relationship to chromium carcinogenesis (review).

This work has utilized cellular, molecular, pharmacological, and genetic approaches to understand the interrelationship between Cr-induced genotoxicity, apoptosis and carcinogenesis and hopes this review will clarify existing concepts and also introduce novel perspectives in chromium carcinogenesis research.

Neurotoxicants and neurobiological function : effects of organoheavy metals

Organomercury, Lead and Tin Compounds in the Environment and the Potential for Human Exposure Neuropathological Changes Associated with Accidental or Experimental Exposure to Organometallic

Chelating agents in medicine.

This particular review deals with the toxic effects of this dose-response curve and the use of chelating agents to remove execessive quantities of metal ions which are producing toxic effects.

An update on exposure and effects of lead.

  • B. D. Beck
  • Environmental Science
    Fundamental and applied toxicology : official journal of the Society of Toxicology
  • 1992

A review of thallium toxicity.

The principal clinical features of thallotoxicosis are gastroenteritis, peripheral neuropathy of unknown etiology, and alopecia, and the presence of elevated Tl levels in the urine or other biologic materials confirms the diagnosis.


The principal clinical features of thallotoxicosis are gastroenteritis, peripheral neuropathy of unknown etiology, and alopecia, and the presence of elevated Tl levels in the urine or other biologic materials confirms the diagnosis.

Occupational lead exposure, nephropathy, and renal cancer.

A 48-year-old lead worker was found to have a cystic renal carcinoma during an evaluation of his occupational lead poisoning, adding increased evidence to the concern over the carcinogenic potential of prolonged lead exposure.