• Corpus ID: 74434237

Toxic effects of metals

  title={Toxic effects of metals},
  author={Robert A. Goyer and Thomas W. Clarkson},
Essentiality Toxicity Carcinogenicity Lead(Pb) Exposure Toxicokinetics Toxicity Neurologic, Neurobehavioral, and Developmental Effects in Children Mechanisms of Effects on the Developing Nervous System Peripheral Neuropathy Hematologic Effects Renal Toxicity Lead and Gout Effects on Cardiovascular System Immunotoxicity Bone Effects Reproductive Effects Birth Outcomes Carcinogenicity Other Effects Dose Response Treatment Organic Lead Compounds Mercury (Hg) Exposure Disposition and Toxicokinetics… 
Nickel, its adverse health effects & oxidative stress.
A selective review on nickel and effect of its acute, subchronic and chronic doses on certain metabolically active tissues in human as well as animals is presented.
Cadmium, Lead, Thallium: Occurrence, Neurotoxicity and Histopathological Changes of the Nervous System
Neuropathology is frequently used to evaluate the effects of toxic agents on nervous system organization and cellular components; thus, careful histologic evaluations increase knowledge of the neurotoxicity of heavy metals.
Chemical and biological properties of toxic metals and use of chelating agents for the pharmacological treatment of metal poisoning
The present review attempts to provide updated information about the mechanisms, the cellular targets and the effects of toxic metals.
Dietary Strategies for the Treatment of Cadmium and Lead Toxicity
The evidence for protective effects of essential metals, vitamins, edible plants, phytochemicals, probiotics and other dietary supplements against Cd and Pb toxicity is reviewed and the proposed possible mechanisms are described.
This review gives details about some heavy metals and their toxicity mechanisms, along with their health effects.
Heavy metal induced oxidative stress & its possible reversal by chelation therapy.
A comprehensive account of recent developments in the research on heavy metal poisoning particularly the role of oxidative stress/free radicals in the toxic manifestation is attempted, an update about the recent strategies for the treatment with chelating agents and a possible beneficial role of antioxidants supplementation to achieve the optimum effects are attempted.
Health Effects of Chronic Arsenic Exposure
In South Korea, it is believed that biological exposure assessment should be the first step, followed by regular health effect assessments, and objective estimates of exposure levels are needed.


Cadmium and Health: A Toxicological and Epidemiological Appraisal
This book contains the following chapters: Respiratory Effects. Renal Effects. Effects on Bone, on Vitamin D, and Calcium Metabolism. Other Toxic Effects. Carcinogenic and Genetic Effects. Critical
Usefulness of biomarkers of exposure to inorganic mercury, lead, or cadmium in controlling occupational and environmental risks of nephrotoxicity.
Monitoring HgU is useful for controlling the nephrotoxic risk of overexposure to inorganic mercury; HGU should not exceed 50 micrograms Hg/g creatinine in order to prevent cytotoxic and functional renal effects.
Occupational and environmental chemical hazards: Cellular and biochemical indices for monitoring toxicity
This book deals with the tools applicable to the investigation of chemical toxicity in a variety of organs in the human host, and discusses of indices in current or proposed use for toxic effects on hepatic, renal, and nervous system functions in porphyrin metabolism.
Nutrition and metal toxicity.
  • R. Goyer
  • Biology
    The American journal of clinical nutrition
  • 1995
Dietary deficiencies of calcium, iron, and zinc enhance the effects of lead on cognitive and behavioral development and Selenium protects from mercury and methyl mercury toxicity by preventing damage from free radicals or by forming inactive selenium mercury complexes.
Chromium-induced genotoxicity and apoptosis: relationship to chromium carcinogenesis (review).
This work has utilized cellular, molecular, pharmacological, and genetic approaches to understand the interrelationship between Cr-induced genotoxicity, apoptosis and carcinogenesis and hopes this review will clarify existing concepts and also introduce novel perspectives in chromium carcinogenesis research.
Neurotoxicants and neurobiological function : effects of organoheavy metals
Organomercury, Lead and Tin Compounds in the Environment and the Potential for Human Exposure Neuropathological Changes Associated with Accidental or Experimental Exposure to Organometallic
Lead toxicity: from overt to subclinical to subtle health effects.
  • R. Goyer
  • Medicine
    Environmental health perspectives
  • 1990
Current research implicates lead as a contributing etiologic factor in a number of common diseases affecting large portions of the population such as subtle cognitive and neurological deficits, hypertension, congenital malformations, immunotoxicity, and deficits in growth and development.
Chelating agents in medicine.
This particular review deals with the toxic effects of this dose-response curve and the use of chelating agents to remove execessive quantities of metal ions which are producing toxic effects.
An update on exposure and effects of lead.
  • B. D. Beck
  • Environmental Science
    Fundamental and applied toxicology : official journal of the Society of Toxicology
  • 1992
A review of thallium toxicity.
The principal clinical features of thallotoxicosis are gastroenteritis, peripheral neuropathy of unknown etiology, and alopecia, and the presence of elevated Tl levels in the urine or other biologic materials confirms the diagnosis.