Toxic effects of MDMA on central serotonergic neurons in the primate: importance of route and frequency of drug administration.

@article{Ricaurte1988ToxicEO,
  title={Toxic effects of MDMA on central serotonergic neurons in the primate: importance of route and frequency of drug administration.},
  author={George A. Ricaurte and L E Delanney and Ian Irwin and James William Langston},
  journal={Brain research},
  year={1988},
  volume={446 1},
  pages={165-8}
}
This study compared the toxic effects of oral versus subcutaneous and single versus multiple doses of 3,4-methylenedioxymethamphetamine (MDMA) on central serotonergic neurons in non-human primates. Orally administered MDMA was approximately one-half as effective as subcutaneously administered drug. Multiple doses were more effective than single doses, but a single 5 mg/kg dose of MDMA given orally still produced a long-lasting depletion of serotonin in the monkey brain. These results indicate… CONTINUE READING