Toxic effect of zinc nanoscale metal-organic frameworks on rat pheochromocytoma (PC12) cells in vitro.

@article{Ren2014ToxicEO,
  title={Toxic effect of zinc nanoscale metal-organic frameworks on rat pheochromocytoma (PC12) cells in vitro.},
  author={Fei Ren and Baochun Yang and Jing Cai and Yaodong Jiang and Jun Xu and Shan Wang},
  journal={Journal of hazardous materials},
  year={2014},
  volume={271},
  pages={
          283-91
        }
}
Metal-organic frameworks (MOFs) possess unique properties desirable for delivery of drugs and gaseous therapeutics, but their uncharacterized interactions with cells raise increasing concerns of their safety in such biomedical applications. We evaluated the adverse effects of zinc nanoscale MOFs on the cell morphology, cytoskeleton, cell viability and expression of neurotrophin signaling pathway-associated GAP-43 protein in rat pheochromocytoma PC12 cells. At the concentration of 25 μg/ml, zinc… CONTINUE READING

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