Toxic effect of vepesid on morphology and function of the rat liver


Intravenous injection of antitumor drug vepeside in the maximum tolerated dose (MTD) stimulated free radical oxidation processes in rats. Activities of blood aminotransferases and alkaline phosphatase changed. Morphological study of the liver revealed fatty degeneration, hepatocyte necrosis, and inflammatory infiltration. 
DOI: 10.1007/s10517-007-0073-3

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