Toxic effect of troglitazone on cultured rat hepatocytes.

  title={Toxic effect of troglitazone on cultured rat hepatocytes.},
  author={Yasuyuki Toyoda and Atsushi Tsuchida and E Iwami and Ichitomo Miwa},
  journal={Life sciences},
  volume={68 16},
We examined the cytotoxicity of troglitazone toward cultured rat hepatocytes. The drug concentration- and time-dependently decreased cell viability and increased lactate dehydrogenase leakage from the cells. Troglitazone-induced cell death was characterized by "DNA ladders", condensation of nuclei, and a positive reaction to in situ nick-end labeling. The results indicate that troglitazone can cause apoptotic cell death in cultured rat hepatocytes. 

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