Toxic effect of concomitant administration of cyclosporin A and acyclovir on renal function and morphology in rats

Abstract

The immunosuppressive agent cyclosporin A (CyA) and the antiviral drug acyclovir may cause renal functional impairment. CyA-induced immunosuppression increases the rate of viral infections. Therefore we were interested to determine whether short-term co-administration of CyA and acyclovir involves an increased nephrotoxic risk. Male Wistar rats were treated… (More)
DOI: 10.1007/s002040050427

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