Toxic and nontoxic effects of ouabain on the transmitter release from frog motor nerve terminals.

@article{Mano1995ToxicAN,
  title={Toxic and nontoxic effects of ouabain on the transmitter release from frog motor nerve terminals.},
  author={Takashi Ma{\'e}no and Koh-ichi Enomoto and Nobumasa Hara and Masashi Sawada and Masashi Ichinose},
  journal={The Japanese journal of physiology},
  year={1995},
  volume={45 1},
  pages={85-95}
}
Toxic and nontoxic effects of ouabain were investigated on frog neuromuscular preparation by measuring the mean quantal content of endplate potentials elicited during repetitive nerve stimulation. In the untreated normal muscles, application of 10 microM ouabain gave rise to a slow exponential increase in the transmitter release (toxic ouabain effect) with a certain delay. This delay was increased with either 100 microM amiloride, a Na(+)-Ca2+ exchange blocker, or the intracellular loading of 1… CONTINUE READING