Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives

@inproceedings{Cascio2019ToxicTO,
  title={Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives},
  author={Filippa Lo Cascio and Nicha Puangmalai and Anna Ellsworth and Fabio Bucchieri and Andrea Pace and Antonio Palumbo Piccionello and Rakez Kayed},
  booktitle={Scientific reports},
  year={2019}
}
The pathological aggregation and accumulation of tau, a microtubule-associated protein, is a common feature amongst more than 18 different neurodegenerative diseases that are collectively known as tauopathies. Recently, it has been demonstrated that the soluble and hydrophobic tau oligomers are highly toxic in vitro due to their capacity towards seeding tau misfolding, thereby propagating the tau pathology seen across different neurodegenerative diseases. Modulating the aggregation state of tau… CONTINUE READING

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SHOWING 1-10 OF 22 REFERENCES

A novel serine racemase inhibitor suppresses neuronal over-activation in vivo.

VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Synthesis of Calebin-A and its Biologically Active Analogs

  • Majeed, Nagabhushanam, Kalyanam, Anju Majeed, Samuel Manoharan. Thomas
  • United States patent Eur. Pat
  • 2016

Novel Compound Using Ferulic Acid as Raw Material and Organic Electroluminescent Element Using the Novel Compound

  • K. Inoue, Koshitani, +9 authors Takashi
  • JP 2013014525
  • 2013