Toxic Effects of Tacrine on Primary Hepatocytes and Liver Epithelial Cells in Culture

@article{LagadicGossmann1998ToxicEO,
  title={Toxic Effects of Tacrine on Primary Hepatocytes and Liver Epithelial Cells in Culture},
  author={Dominique Lagadic-Gossmann and M. Y. Rissel and M. A. Le Bot and Andr{\'e} Guillouzo},
  journal={Cell Biology and Toxicology},
  year={1998},
  volume={14},
  pages={361-373}
}
Administration of tacrine (THA) for the treatment of Alzheimer's disease results in a reversible hepatotoxicity in 30–50% of patients, as indicated by an increase in transaminase levels. However, the intracellular mechanisms underlying such a toxicity have not yet been elucidated. In this study, we performed short-term and long-term in vitro treatments on primary human and rat hepatocyte cultures as well as on nonparenchymal rat liver epithelial cells (RLEC), known as CYP1A-deficient cells… CONTINUE READING