Towards understanding molecular mechanisms of action of homeopathic drugs: An overview

@article{KhudaBukhsh2004TowardsUM,
  title={Towards understanding molecular mechanisms of action of homeopathic drugs: An overview},
  author={Anisur Rahman Khuda-Bukhsh},
  journal={Molecular and Cellular Biochemistry},
  year={2004},
  volume={253},
  pages={339-345}
}
The homeopathic mode of treatment often encourages use of drugs at such ultra-low doses and high dilutions that even the physical existence of a single molecule of the original drug substance becomes theoretically impossible. But homeopathy has sustained for over two hundred years despite periodical challenges thrown by scientists and non-believers regarding its scientificity. There has been a spurt of research activities on homeopathy in recent years, at clinical, physical, chemical… Expand
Homeopathic drug discovery: theory update and methodological aspect
TLDR
Although some areas of concern remain, research carried out so far both in vitro and in vivo validates the effects of highly diluted homeopathic medicines in a wide variety of organisms. Expand
Current trends in high dilution research with particular reference to gene regulatory hypothesis
TLDR
The present review focuses mainly on research in support of the gene regulatory hypothesis, and mention has been made of some relevant physical and biological aspects at cellular and molecular levels. Expand
Laboratory Research in Homeopathy: Pro
TLDR
This review and its companion piece in this issue are composed of a thesis section, a response section in reaction to the companion thesis, and a rebuttal section to address issues raised in the companion response. Expand
Immunology and Homeopathy. 1. Historical Background
TLDR
The historical origins of homeopathy, the laboratory and animal models related to the field of immunopharmacology, the clinical evidence in favor and against the use of homeopathic in the inflammatory diseases and the hypotheses regarding its action mechanism are reviewed. Expand
Alternative Homeopathic Therapy for Cancer Treatment: The Psorinum Therapy
TLDR
With solid support of objective evidence about effectiveness, oncologists now have a positive opinion about this alternative therapy called the „Psorinum‟ therapy and the evolution of this therapy is discussed. Expand
Laboratory Research in Homeopathy: Con
TLDR
The debate presented here concerns the utility of animal studies on cancer treatment with homeopathic preparations and a response section in reaction to the companion thesis, and a rebuttal section to address issues raised in the companion response. Expand
Investigation of therapeutically active constituents of homeopathy medicine from Justicia adhatoda L. and its clinical verification
In homeopathy system of medicine, Justicia adhatoda has been used in the treatment of cold, cough, pneumonia, fever, jaundice, whooping cough and asthma. We have tested the mother tincture, 6c andExpand
Homeopathic Treatment and Prevention of Hepatitis C
TLDR
The importance of Homeopathic extort in the treatment of hepatitis C in three cases, who suffer from hepatitis with different age group, are estimated, which may help to categorize and improve applicable combinations or Homeopathic products useful in the management of hepatitis. Expand
Isopathic Use of Auto-Sarcode of DNA as Anti-Miasmatic Homeopathic Medicine and Modulator of Gene Expression?
TLDR
It is inferred that disease-promoting epigenetic alterations are the biological representation of the chronic miasms, suggesting the isopathic use of auto-sarcode of DNA as homeopathic therapeutic modulator of gene expression for the management of chronic diseases. Expand
Evidence in support of gene regulatory hypothesis: Gene expression profiling manifests homeopathy effect as more than placebo
TLDR
Results indicate that action of the potentized drugs was “more than placebo” and these ultra-highly diluted drugs acted primarily through modulation of gene expression. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 73 REFERENCES
Potentized homoeopathic drugs act through regulation of gene-expression: a hypothesis to explain their mechanism and pathways of action in vitro
TLDR
This model is partly substantiated from research data on repair of chromosomal damages in X-irradiated or toxic chemical-treated mice by the oral administration of some potentized homoeopathic drugs, and from some of the unpublished and published works of other researchers in the field of homoeopathy. Expand
Molecular mechanism of biological responses to homoeopathic medicines.
TLDR
Examination of the probable protein-microcrystal interaction is examined, forcusing on the cases in which silicon dioxide (silica) microcrystals cause inflammation and in which hydrate microcrystal may be formed during general anesthesia. Expand
Comparative efficacy of two microdoses of a potentized homoeopathic drug, Cadmium Sulphoricum, in reducing genotoxic effects produced by cadmium chloride in mice: a time course study
TLDR
Both Cad Sulph-30 and 200 were able to combat cadmium induced genotoxic effects in mice and that combined pre- and post- feeding mode of administration was found to be most effective in reducing the genot toxic effect of CdCl2 followed by the post-feeding mode. Expand
A controlled evaluation of a homoeopathic preparation in the treatment of influenza-like syndromes.
TLDR
The proportion of cases who recovered within 48 h of treatment was greater among the active drug group than among the placebo group, and the result cannot be explained given the present state of knowledge, but it calls for further rigorously designed clinical studies. Expand
Effect of a homeopathic drug, Chelidonium, in amelioration of p-DAB induced hepatocarcinogenesis in mice
TLDR
The homeopathic drug Chelidonium exhibited anti-tumor and anti-genotoxic activities and also favorably modulated activities of some marker enzymes in mice compared to suitable controls. Expand
Effect of homeopathic treatment on fibrositis (primary fibromyalgia)
TLDR
In conclusion, interstitial laser hyperthermia is feasible and seems to be safe and the combination of technologies may be valuable for treating otherwise untreatable tumours in a range of solid organs and for the primary treatment of small neoplasms. Expand
Efficacy of a potentized homoeopathic drug (Arsenicum-album-30) in reducing cytotoxic effects produced by arsenic trioxide in mice: III. Enzymatic changes and recovery of tissue damage in liver.
TLDR
The homoeopathic drug is capable of preventing or repairing liver damage induced by arsenic trioxide and the positive changes were also confirmed by the activities of the enzymatic markers. Expand
Is evidence for homoeopathy reproducible?
TLDR
The reproducibility of evidence in favour of homoeopathy proof of its activity or proof of the clinical trial's capacity to produce false-positive results is tested. Expand
Efficacy of a potentized homoeopathic drug (Arsenicum Album-30) in reducing toxic effects produced by arsenic trioxide in mice: II. On alterations in body weight, tissue weight and total protein.
TLDR
In arsenic treated mice orally administered with the homoeopathic drug statistically significant increases were noted in the weights of individual tissue weight, protein content as well as the mean body weight as compared to their respective controls. Expand
IS HOMOEOPATHY A PLACEBO RESPONSE? CONTROLLED TRIAL OF HOMOEOPATHIC POTENCY, WITH POLLEN IN HAYFEVER AS MODEL
TLDR
No evidence emerged to support the idea that placebo action fully explains the clinical responses to homoeopathic drugs. Expand
...
1
2
3
4
5
...