Towards understanding molecular mechanisms of action of homeopathic drugs: An overview

  title={Towards understanding molecular mechanisms of action of homeopathic drugs: An overview},
  author={Anisur Rahman Khuda-Bukhsh},
  journal={Molecular and Cellular Biochemistry},
  • A. Khuda-Bukhsh
  • Published 1 November 2003
  • Medicine
  • Molecular and Cellular Biochemistry
The homeopathic mode of treatment often encourages use of drugs at such ultra-low doses and high dilutions that even the physical existence of a single molecule of the original drug substance becomes theoretically impossible. But homeopathy has sustained for over two hundred years despite periodical challenges thrown by scientists and non-believers regarding its scientificity. There has been a spurt of research activities on homeopathy in recent years, at clinical, physical, chemical… 

Homeopathic drug discovery: theory update and methodological aspect

Although some areas of concern remain, research carried out so far both in vitro and in vivo validates the effects of highly diluted homeopathic medicines in a wide variety of organisms.

Current trends in high dilution research with particular reference to gene regulatory hypothesis

The present review focuses mainly on research in support of the gene regulatory hypothesis, and mention has been made of some relevant physical and biological aspects at cellular and molecular levels.

Laboratory Research in Homeopathy: Pro

This review and its companion piece in this issue are composed of a thesis section, a response section in reaction to the companion thesis, and a rebuttal section to address issues raised in the companion response.

Immunology and Homeopathy. 1. Historical Background

The historical origins of homeopathy, the laboratory and animal models related to the field of immunopharmacology, the clinical evidence in favor and against the use of homeopathic in the inflammatory diseases and the hypotheses regarding its action mechanism are reviewed.

Alternative Homeopathic Therapy for Cancer Treatment: The Psorinum Therapy

With solid support of objective evidence about effectiveness, oncologists now have a positive opinion about this alternative therapy called the „Psorinum‟ therapy and the evolution of this therapy is discussed.

Laboratory Research in Homeopathy: Con

The debate presented here concerns the utility of animal studies on cancer treatment with homeopathic preparations and a response section in reaction to the companion thesis, and a rebuttal section to address issues raised in the companion response.

Investigation of therapeutically active constituents of homeopathy medicine from Justicia adhatoda L. and its clinical verification

In homeopathy system of medicine, Justicia adhatoda has been used in the treatment of cold, cough, pneumonia, fever, jaundice, whooping cough and asthma. We have tested the mother tincture, 6c and

Homeopathic Treatment and Prevention of Hepatitis C

The importance of Homeopathic extort in the treatment of hepatitis C in three cases, who suffer from hepatitis with different age group, are estimated, which may help to categorize and improve applicable combinations or Homeopathic products useful in the management of hepatitis.

Isopathic Use of Auto-Sarcode of DNA as Anti-Miasmatic Homeopathic Medicine and Modulator of Gene Expression?

It is inferred that disease-promoting epigenetic alterations are the biological representation of the chronic miasms, suggesting the isopathic use of auto-sarcode of DNA as homeopathic therapeutic modulator of gene expression for the management of chronic diseases.

Evidence in support of gene regulatory hypothesis: Gene expression profiling manifests homeopathy effect as more than placebo

Results indicate that action of the potentized drugs was "more than placebo” and these ultra-highly diluted drugs acted primarily through modulation of gene expression.



Molecular mechanism of biological responses to homoeopathic medicines.

Comparative efficacy of two microdoses of a potentized homoeopathic drug, Cadmium Sulphoricum, in reducing genotoxic effects produced by cadmium chloride in mice: a time course study

Both Cad Sulph-30 and 200 were able to combat cadmium induced genotoxic effects in mice and that combined pre- and post- feeding mode of administration was found to be most effective in reducing the genot toxic effect of CdCl2 followed by the post-feeding mode.

A controlled evaluation of a homoeopathic preparation in the treatment of influenza-like syndromes.

The proportion of cases who recovered within 48 h of treatment was greater among the active drug group than among the placebo group, and the result cannot be explained given the present state of knowledge, but it calls for further rigorously designed clinical studies.

Effect of a homeopathic drug, Chelidonium, in amelioration of p-DAB induced hepatocarcinogenesis in mice

The homeopathic drug Chelidonium exhibited anti-tumor and anti-genotoxic activities and also favorably modulated activities of some marker enzymes in mice compared to suitable controls.

Effect of homeopathic treatment on fibrositis (primary fibromyalgia)

In conclusion, interstitial laser hyperthermia is feasible and seems to be safe and the combination of technologies may be valuable for treating otherwise untreatable tumours in a range of solid organs and for the primary treatment of small neoplasms.

Efficacy of a potentized homoeopathic drug (Arsenicum-album-30) in reducing cytotoxic effects produced by arsenic trioxide in mice: III. Enzymatic changes and recovery of tissue damage in liver.

The homoeopathic drug is capable of preventing or repairing liver damage induced by arsenic trioxide and the positive changes were also confirmed by the activities of the enzymatic markers.