Towards the therapeutic use of intranasal neuropeptide administration in metabolic and cognitive disorders.

@article{Hallschmid2008TowardsTT,
  title={Towards the therapeutic use of intranasal neuropeptide administration in metabolic and cognitive disorders.},
  author={Manfred Hallschmid and Christian Benedict and Bernd Schultes and Boris Perras and Horst-Lorenz Fehm and Werner Kern and Jan Born},
  journal={Regulatory peptides},
  year={2008},
  volume={149 1-3},
  pages={79-83}
}
The nose provides an effective way for delivering neuropeptides to the central nervous system, bypassing the blood-brain barrier and avoiding systemic side effects. Thereby intranasal neuropeptide administration enables the modulation of central nervous signaling pathways of body weight regulation and cognitive functions. Central nervous control of energy homeostasis is assumed to rely on hypothalamic neuropeptidergic pathways that are triggered by the peripheral adiposity signals insulin and… CONTINUE READING