Towards the pharmacotherapy of eating disorders

@article{Pederson2003TowardsTP,
  title={Towards the pharmacotherapy of eating disorders},
  author={Kristine J Pederson and James L Roerig and James E Mitchell},
  journal={Expert Opinion on Pharmacotherapy},
  year={2003},
  volume={4},
  pages={1659 - 1678}
}
The purpose of this review is to discuss pharmacological options for the treatment of patients with eating disorders. Sequentially described are pharmacotherapy studies of anorexia nervosa (AN), bulimia nervosa (BN) and binge-eating disorder (BED). The quantity of drug trials performed with AN patients has been very limited. While the majority of studies have failed to show medication efficacy for the acute treatment of AN, there is data which suggests that fluoxetine hydrochloride may play a… 
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References

SHOWING 1-10 OF 208 REFERENCES
Combining pharmacotherapy and psychotherapy in the treatment of patients with eating disorders.
Pharmacotherapy of bulimia nervosa and binge eating disorder: longer-term outcomes.
  • W. Agras
  • Psychology, Medicine
    Psychopharmacology bulletin
  • 1997
TLDR
The longer-term effects of antidepressant medication, with and without the addition of psychotherapy, for the treatment of bulimia nervosa and binge eating disorder are reviewed and there is evidence that antidepressant treatment combined with CBT is more effective than placebo plus CBT.
Does fluoxetine augment the inpatient treatment of anorexia nervosa?
TLDR
Fluoxetine does not appear to add significant benefit to the inpatient treatment of anorexia nervosa and there were no significant differences in clinical outcome on any measure between patients receiving fluoxettine and patients receiving placebo.
Medication and psychotherapy in the treatment of bulimia nervosa.
TLDR
At present, cognitive-behavioral therapy is the psychological treatment of choice for bulimia nervosa and a two-stage medication intervention using fluoxetine adds modestly to the benefit of psychological treatment.
Psychotherapy for bulimia nervosa and binging.
TLDR
CBT in a full or less intensive form is not significantly superior to CBT in a pure self-help form and CBT augmented by exposure and response therapy, and non CBT-psychotherapies also have significantly greater abstinence rates in comparisons with wait-list controls.
Fluvoxamine in the treatment of binge-eating disorder: a multicenter placebo-controlled, double-blind trial.
TLDR
In this placebo-controlled trial, fluvoxamine was found to be effective according to most outcome measures in the acute treatment of binge-eating disorder.
Sertraline in the treatment of restricting anorexia nervosa: an open controlled trial.
TLDR
An open, controlled trial of sertraline in a sample of 11 restricting-type anorexics, treated in an outpatient setting, compared with a control group of patients with similar characteristics, finding a significantly greater improvement in depressive symptoms, ineffectiveness, lack of interoceptive awareness, and perfectionism.
An open trial of fluoxetine in patients with anorexia nervosa.
TLDR
Fluoxetine may help patients with anorexia nervosa maintain a healthy body weight as outpatients and the agent may help by improving eating behavior and/or reducing obsessionality, depression, and anxiety.
Fluvoxamine in prevention of relapse in bulimia nervosa: effects on eating-specific psychopathology.
TLDR
Two further variables showed the superior relapse prevention effects of fluvoxamine compared with placebo for the completer sample, while they did not reach significance for group-by-time interactions in the intent-to-treat sample.
Intensive Nutritional Counselling in Bulimia Nervosa: A Role for Supplementation with Fluoxetine?
TLDR
Nutritional counselling is an effective means of treating bulimia nervosa, with improvement maintained up to 3 months follow-up, and the addition of fluoxetine 3 × 20 mg/day confers additional benefit.
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