Towards the Small and the Beautiful: A Small Dibromotyrosine Derivative from Pseudoceratina sp. Sponge Exhibits Potent Apoptotic Effect through Targeting IKK/NFκB Signaling Pathway

  title={Towards the Small and the Beautiful: A Small Dibromotyrosine Derivative from Pseudoceratina sp. Sponge Exhibits Potent Apoptotic Effect through Targeting IKK/NF$\kappa$B Signaling Pathway},
  author={Jui Hsin Su and Yu-Cheng Chen and Mohamed El‐Shazly and Ying-Chi Du and Chiang-Wen Su and Chia-Wei Tsao and Li-lian Liu and Yalan Chou and Wen-Been Chang and Yin-Di Su and Michael Yen-Nan Chiang and Yao-Tsung Yeh and Mei-Chin Lu},
  journal={Marine Drugs},
  pages={3168 - 3185}
A dibromotyrosine derivative, (1′R,5′S,6′S)-2-(3′,5′-dibromo-1′,6′-dihydroxy-4′-oxocyclohex-2′-enyl) acetonitrile (DT), was isolated from the sponge Pseudoceratina sp., and was found to exhibit a significant cytotoxic activity against leukemia K562 cells. Despite the large number of the isolated bromotyrosine derivatives, studies focusing on their biological mechanism of action are scarce. In the current study we designed a set of experiments to reveal the underlying mechanism of DT cytotoxic… 

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