Towards targeted epigenetic therapy of cancer.

  title={Towards targeted epigenetic therapy of cancer.},
  author={Zvonko Magi{\'c} and Gordana Supi{\'c} and Mirjana V. Brankovic-Magic},
  journal={Journal of B.U.ON. : official journal of the Balkan Union of Oncology},
  volume={14 Suppl 1},
Increasing number of publications in the last 10 years implicated that cancer development depends, except genetic alterations, also on inheritable gene expression patterns that are not bound to DNA sequence alterations. These epigenetic mechanisms manifest mostly through changes in chromatin packing and in localized gene promoter changes that influence the transcription of the genes involved in carcinogenesis. These changes are mitoticaly inheritable and potentially reversible, providing large… CONTINUE READING

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