Towards symmetry driven and nature inspired UV filter design

  title={Towards symmetry driven and nature inspired UV filter design},
  author={Michael D. Horbury and Emily L Holt and Louis M. M. Mouterde and Patrick Balaguer and Juan Cebri{\'a}n and Laurent Blasco and Florent Allais and Vasilios G. Stavros},
  journal={Nature Communications},
In plants, sinapate esters offer crucial protection from the deleterious effects of ultraviolet radiation exposure. These esters are a promising foundation for designing UV filters, particularly for the UVA region (400 – 315 nm), where adequate photoprotection is currently lacking. Whilst sinapate esters are highly photostable due to a cis-trans (and vice versa) photoisomerization, the cis-isomer can display increased genotoxicity; an alarming concern for current cinnamate ester-based human… 
UV Filters: Challenges and Prospects
The use of sunscreens is an established and recommended practice to protect skin from solar-induced damage. Around 30 UV filters can be used in sunscreen products in the European Union, which ought
Unravelling the Photoprotective Mechanisms of Nature-Inspired Ultraviolet Filters Using Ultrafast Spectroscopy
The relaxation mechanism of a molecule after it has been photoexcited can be unravelled by several techniques, the ones of most interest for this review being ultrafast spectroscopy and computational methods.
A Perspective on Femtosecond Pump–Probe Spectroscopy in the Development of Future Sunscreens
Given the negative impacts of overexposure to ultraviolet radiation (UVR) on humans, sunscreens have become a widely used product. Certain ingredients within sunscreens are responsible for
Excited-state dynamics of isolated and (micro)solvated methyl sinapate: the bright and shady sides of a natural sunscreen
ABSTRACT The increasing awareness of the adverse effects of exposure to UV radiation in combination with the conclusion that presently employed sunscreen agents are far from optimal has led to the
Determining the photostability of avobenzone in sunscreen formulation models using ultrafast spectroscopy.
It was found that there was an apparent concentration dependence on the long-term photoprotective efficacy of these mixtures, which could be linked to the ultrafast photodynamics by the presence of a ground-state bleach offset.
Innovative Bio-Based Organic UV-A and Blue Light Filters from Meldrum’s Acid
Meldrum’s acid derivatives are not only competitive when benchmarked against organic filters currently on the market (i.e., avobenzone), but they also do not exhibit any endocrine disruption activity.
Sinapic Acid Esters: Octinoxate Substitutes Combining Suitable UV Protection and Antioxidant Activity
A wide library of p-hydroxycinnamic esters deriving from naturally occurring sinapic acid has been synthesized using a Knoevenagel–Doebner condensation, showing promising UVB protection and antioxidant efficacy.
Unravelling the Photoprotection Properties of Garden Cress Sprout Extract
The result suggests that Detoxophane nc containing the garden cress sprout extract may offer additional photoprotection to the end user in the form of a UV filter booster.
Biomimetic regioselective and high-yielding Cu(i)-catalyzed dimerization of sinapate esters in green solvent Cyrene™: towards sustainable antioxidant and anti-UV ingredients
Naturally occurring sinapic acid and its esters are anti-UV and antiradical chemicals. This work aimed at designing an industrially relevant sustainable synthetic pathway allowing their selective
Sustainable synthesis, in silico evaluation of potential toxicity and environmental fate, antioxidant and UV-filtering/photostability activity of phenolic-based thiobarbituric derivatives
ABSTRACT The recent ban of some organic UV-filters – such as oxybenzone or octinoxate – considered toxic for coral reef, has heightened the need for eco-friendly alternatives, especially those


Ultrafast Barrierless Photoisomerization and Strong Ultraviolet Absorption of Photoproducts in Plant Sunscreens.
This work explains nature's selection of sinapoyl malate rather than sinapic acid as the plant sunscreen molecule by utilizing femtosecond transient absorption spectroscopy and time-dependent density functional theory.
Sunscreens: are they beneficial for health? An overview of endocrine disrupting properties of UV-filters.
It seems pertinent to evaluate whether exposure to UV-filters contribute to possible adverse effects on the developing organs of foetuses and children, although human exposure is high as UV- Filters in sunscreens are rapidly absorbed from the skin.
In vitro assessment of the broad-spectrum ultraviolet protection of sunscreen products.
Determination of critical wavelength by means of UV substrate spectrophotometry provides a rapid, inexpensive, and reliable measure of broad-spectrum protection, which is largely independent of SPF, yet ensures long-wavelength UVA protection commensurate with SPF.
Investigating isomer specific photoprotection in a model plant sunscreen.
Following a novel Z-ethyl sinapate synthesis, it is demonstrated that photoprotection is isomer independent, which suggests that, regarding photoprotsection, there were no evolutionary pressures for biosynthesis of either isomer.
Photoprotection: facts and controversies.
Issues concerning the most recent lines of research in the exploration of modern methods of photoprotection both local and systemic, such as with the use of photolyase or examination of various enzymes repairing damage after sun exposure are addressed, as well as the promising future in photoprotsection technology.
Sunscreen use: controversies, challenges and regulatory aspects
Future debates on sunscreens are likely to focus on nanoparticles and environmental issues, along with motivation campaigns to persuade consumers to protect their skin.
Ab initio study of potential ultrafast internal conversion routes in oxybenzone, caffeic acid, and ferulic acid: implications for sunscreens.
Ab initio calculations designed to explore the excited state nonradiative relaxation pathways that provide photostability toxybenzone and ferulic acid and the photoprotection they offer toward UV-A and UV-B radiation suggest FA might be superior to CA as a sunscreen ingredient.
Towards elucidating the photochemistry of the sunscreen filter ethyl ferulate using time-resolved gas-phase spectroscopy.
Ultrafast time-resolved ion yield (TR-IY) and velocity map imaging spectroscopies are employed to reveal the relaxation dynamics after photoexcitation in ethyl 4-hydroxy-3-methoxycinnamate (ethyl
On the absorbance changes in the photocycle of the photoactive yellow protein: A quantum-chemical analysis
  • V. Molina, M. Merchán
  • Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 2001
The results suggest the low-temperature photoproduct PYPHL as the most plausible candidate for the assignment of the cryogenically trapped early intermediate (Genick et al.), and demonstrate that a combined analysis of high-level theoretical results and experimental data can be of great value to perform assignments of detected intermediates in a photocycle.