Towards selective pharmacological modulation of protein kinase C--opportunities for the development of novel antineoplastic agents.

@article{Gescher1992TowardsSP,
  title={Towards selective pharmacological modulation of protein kinase C--opportunities for the development of novel antineoplastic agents.},
  author={A. Gescher},
  journal={British Journal of Cancer},
  year={1992},
  volume={66},
  pages={10 - 19}
}
The biochemistry of the cell membrane and cellular signalling systems have recently come to the fore as potential targets for the discovery and development of new anticancer drugs (Tritton & Hickman, 1990; Powis, 1991). As part of this new focus natural products with potentially exploitable biological properties receive increasing attention. The marine animal product bryostatin 1 is a prototype of such agents. The most prominent biochemical feature of this investigational drug is its ability to… CONTINUE READING

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Differential effects of bryostatial and phorbol ester on human breast cancer cell liner

  • M. J. KENNEDY, L. J. PRESTIGIACOMO, G. TYLOR, W. S. MAY, N. E. DAVIDSON
  • Cancer Res.,
  • 1992
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