Towards selective lysophospholipid GPCR modulators.

  title={Towards selective lysophospholipid GPCR modulators.},
  author={Julia K. Archbold and Jennifer L. Martin and Matthew J Sweet},
  journal={Trends in pharmacological sciences},
  volume={35 5},
G-protein-coupled receptors (GPCRs) that recognize the lysophospholipids (LPLs) are grouped into two phylogenetically distinct families: the endothelial differentiation gene (Edg) and non-Edg GPCRs. Owing to their more recent identification, and hindered by a lack of selective pharmacological tools, our understanding of the functions and signaling pathways… CONTINUE READING