Towards proteome-wide production of monoclonal antibody by phage display.

  title={Towards proteome-wide production of monoclonal antibody by phage display.},
  author={Bin Liu and Lan Huang and Carina Sihlbom and Al L. Burlingame and James D Marks},
  journal={Journal of molecular biology},
  volume={315 5},
Sequencing of the human genome reveals that there are approximately 30,000 genes that encode an even greater number of proteins which comprise the human proteome. Characterization of gene products at the genome-wide scale requires the development of high throughput methods to generate temporo-spatial information on each and every protein in the cell under normal and pathological conditions. Monoclonal antibodies are important reagents for these studies. We have developed a method to generate… CONTINUE READING
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