Towards predictive models of stem cell fate

@article{Viswanathan2003TowardsPM,
  title={Towards predictive models of stem cell fate},
  author={Sowmya Viswanathan and Peter W. Zandstra},
  journal={Cytotechnology},
  year={2003},
  volume={41},
  pages={75-92}
}
Quantitative approaches are essential for the advancement of strategies to manipulate stem cells or their derivatives for therapeutic applications. Predictive models of stem cell systems would provide the means to pose and validate non-intuitive hypotheses and could thus serve as an important tool for discerning underlying regulatory mechanisms governing stem cell fate decisions. In this paper we review the development of computational models that attempt to describe mammalian adult and… CONTINUE READING

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Computational Model Based on Ligand/Receptor Signaling Threshold (LIST) Model Predicts Stem Cell Population Dynamic Responses to Leukemia Inhibitory Factor (submitted)

  • S Viswanathan, R Raghu, M Mileikovsky, A Nagy, DA Lauffenburger, PW Zandstra
  • 2002
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Growth Factor Interactions Modulate Competitive Dynamics Between Embryonic Stem Cells and Their Immediate Derivatives (submitted)

  • S Viswanathan, T Benatar, M Mileikovsky, DA Lauffenburger, A Nagy, PW Zandstra
  • 2002
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4 Excerpts

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