Towards precision medicine

@article{Ashley2016TowardsPM,
  title={Towards precision medicine},
  author={Euan A. Ashley},
  journal={Nature Reviews Genetics},
  year={2016},
  volume={17},
  pages={507-522}
}
  • E. Ashley
  • Published 1 September 2016
  • Biology
  • Nature Reviews Genetics
There is great potential for genome sequencing to enhance patient care through improved diagnostic sensitivity and more precise therapeutic targeting. To maximize this potential, genomics strategies that have been developed for genetic discovery — including DNA-sequencing technologies and analysis algorithms — need to be adapted to fit clinical needs. This will require the optimization of alignment algorithms, attention to quality-coverage metrics, tailored solutions for paralogous or low… 
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