Towards optimal design of second-generation immunomodulatory oligonucleotides.


The goal of using of oligodeoxyribonucleotides containing CpG dinucleotides (CpG DNA) as immunomodulatory agents has been realized in recent years. Therapeutic applications of CpG DNA as monotherapies and as adjuvants in combination with vaccines, antibodies, antigens and allergens for a number of disease indications are rapidly expanding, and the safety… (More)


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