Towards novel anti-cancer strategies based on cystatin function.

  title={Towards novel anti-cancer strategies based on cystatin function.},
  author={Daniel Keppler},
  journal={Cancer letters},
  volume={235 2},
Cystatins have recently emerged as important players in a multitude of physiological and patho-physiological settings that range from cell survival and proliferation, to differentiation, cell signaling and immunomodulation. This group of cysteine protease inhibitors forms a large super-family of proteins composed of one, two, three, and, in some species, more than three cystatin domains. Over the last 20 years or so, members of the cystatin super-family have been primarily explored with respect… CONTINUE READING