Towards new models of disease and physiology in the neurosciences: the role of induced and naturally occurring mutations.

@article{Hunter2000TowardsNM,
  title={Towards new models of disease and physiology in the neurosciences: the role of induced and naturally occurring mutations.},
  author={A. Jackie Hunter and Patrick M. Nolan and Steve D. M. Brown},
  journal={Human molecular genetics},
  year={2000},
  volume={9 6},
  pages={893-900}
}
There is a dearth of good mouse models for central nervous system (CNS) disorders. However, the development of gene-targeted technology and the recognition of the importance of the mouse as a model organism have led to the development of a range of behavioural tests for mice. Spontaneous mutations in mice have already provided important information about the role of novel gene products in disorders such as epilepsy and deafness. This has provided the impetus to the establishment of large-scale… CONTINUE READING

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