Towards genetic manipulation of wild mosquito populations to combat malaria: advances and challenges

@article{Riehle2003TowardsGM,
  title={Towards genetic manipulation of wild mosquito populations to combat malaria: advances and challenges},
  author={M. Riehle and Prakash Srinivasan and C. Moreira and M. Jacobs-Lorena},
  journal={Journal of Experimental Biology},
  year={2003},
  volume={206},
  pages={3809 - 3816}
}
  • M. Riehle, Prakash Srinivasan, +1 author M. Jacobs-Lorena
  • Published 2003
  • Medicine, Biology
  • Journal of Experimental Biology
  • SUMMARY Malaria kills millions of people every year, yet there has been little progress in controlling this disease. For transmission to occur, the malaria parasite has to complete a complex developmental cycle in the mosquito. The mosquito is therefore a potential weak link in malaria transmission, and generating mosquito populations that are refractory to the parasite is a potential means of controlling the disease. There has been considerable progress over the last decade towards developing… CONTINUE READING
    72 Citations

    Topics from this paper.

    Using bacteria to express and display anti-parasite molecules in mosquitoes: current and future strategies.
    • 100
    Redressing the sex imbalance in knowledge of vector biology.
    • 80
    Killer Bee Molecules: Antimicrobial Peptides as Effector Molecules to Target Sporogonic Stages of Plasmodium
    • 32
    • PDF
    Comparative and functional genomics of the innate immune system in the malaria vector Anopheles gambiae
    • 226
    Using bacteria to treat diseases
    • 8
    An overview of malaria transmission from the perspective of Amazon Anopheles vectors
    • 47
    • PDF

    References

    SHOWING 1-10 OF 67 REFERENCES
    Bee Venom Phospholipase Inhibits Malaria Parasite Development in Transgenic Mosquitoes*
    • 176
    • PDF
    Anti-mosquito midgut antibodies block development of Plasmodium falciparum and Plasmodium vivax in multiple species of Anopheles mosquitoes and reduce vector fecundity and survivorship
    • A. Lal, P. Patterson, +5 authors A. Azad
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2001
    • 86
    • PDF
    Evolutionary ideas about genetically manipulated mosquitoes and malaria control.
    • 64
    Stable germline transformation of the malaria mosquito Anopheles stephensi
    • 367
    Stable transformation of the yellow fever mosquito, Aedes aegypti, with the Hermes element from the housefly.
    • 341
    • PDF
    Inhibition of malaria parasite development in mosquitoes by anti-mosquito-midgut antibodies.
    • 47
    • PDF
    Engineering blood meal-activated systemic immunity in the yellow fever mosquito, Aedes aegypti.
    • 177
    • PDF
    Bacteria expressing single-chain immunotoxin inhibit malaria parasite development in mosquitoes.
    • 85
    Targeting Plasmodium ligands on mosquito salivary glands and midgut with a phage display peptide library
    • 176
    • PDF
    Molecular strategies to study Plasmodium-mosquito interactions.
    • 18