Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation.

@article{Taylor2001TowardsDC,
  title={Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation.},
  author={Fletcher B. Taylor and Cheng Hock Toh and W. Keith Hoots and Hideo Wada and Marcel Levi},
  journal={Thrombosis and haemostasis},
  year={2001},
  volume={86 5},
  pages={
          1327-30
        }
}
Already in the 19th century some of the first clinical and pathological observations related to DIC were made. [] Key Method Traditionally DIC is diagnosed in association with the following

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References

SHOWING 1-10 OF 16 REFERENCES

Disseminated intravascular coagulation: objective clinical and laboratory diagnosis, treatment, and assessment of therapeutic response.

  • R. Bick
  • Medicine
    Seminars in thrombosis and hemostasis
  • 1996
TLDR
Objective clinical and laboratory criteria for diagnosis of DIC have been delineated, thus avoiding needless confusion and empirical decisions regarding the diagnosis, and objective criteria by which therapy may be stopped when continuation is likely fruitless are presented as a guideline.

Outcome of disseminated intravascular coagulation in relation to the score when treatment was begun. Mie DIC Study Group.

TLDR
It was found that the PT ratio and the levels of antithrombin, plasminogen, PPIC, the PPIC/TAT ratio, and thrombomodulin were related to outcome, suggesting that very high consumption of blood coagulation factors, liver dysfunction, hypofibrinolysis, or organ failure caused a poor outcome.

Soluble fibrin: A predictor for the development and outcome of multiple organ failure

TLDR
Soluble fibrin, a marker of hypercoagulation, seems to predict organ system failure and outcome in ICU patients.

Activation of the extrinsic coagulation pathway in patients with severe sepsis and septic shock.

TLDR
The extrinsic coagulation pathway is activated in patients with severe sepsis and septic shock, and enhanced thrombin generation and activation, and fibrin formation were demonstrated when compared with the control subjects.

Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine.

TLDR
The SOFA score is a simple, but effective method to describe organ dysfunction/failure in critically ill patients and regular, repeated scoring enables patient condition and disease development to be monitored and better understood.

[Disseminated intravascular coagulation].

TLDR
DIC is characterised by evidence of both thrombin and plasmin activation, and may lead to thrombosis in the subacute or chronic form but more often haemorrhage occurs as the clotting factors are exhausted.

Comparison of immunological and functional assays for measurement of soluble fibrin.

TLDR
Two immunologic tests using monoclonal antibodies against fibrin-specific neo-epitopes and two functional tests based on the cofactor activity of soluble fibr in complexes in tPA-induced plasminogen activation are compared.

Studies on the inflammatory-coagulant axis in the baboon response to E. coli: regulatory roles of proteins C, S, C4bBP and of inhibitors of tissue factor.

  • F. Taylor
  • Biology
    Progress in clinical and biological research
  • 1994
TLDR
It has become increasingly clear that the so-called anticoagulant systems which act on the proximal factors of the clotting cascade also attenuate the amplification of the inflammatory response.

Studies on the inflammatory-coagulant axis in the baboon response to E. coli: regulatory roles of proteins C, S, C4bBP and of inhibitors of tissue factor.

TLDR
It has become increasingly clear that the so-called anticoagulant systems which act on the proximal factors of the clotting cascade also attenuate the amplification of the inflammatory response.

A soluble fibrin standard: comparable dose-response with immunologic and functional assays.

A soluble fibrin (SF) preparation has been developed as a potential standard by the Scientific and Standardization Committee for use in assays evaluating in vitro preparations and patient plasma