Towards controlled release of BDNF--manufacturing strategies for protein-loaded lipid implants and biocompatibility evaluation in the brain.

@article{Koennings2007TowardsCR,
  title={Towards controlled release of BDNF--manufacturing strategies for protein-loaded lipid implants and biocompatibility evaluation in the brain.},
  author={Stephanie Koennings and Anne Sapin and Torsten Blunk and Philippe Menei and Achim M Goepferich},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2007},
  volume={119 2},
  pages={163-72}
}
It was the aim of this study to establish triglyceride matrices as potential carriers for long-term release of brain-derived neurotrophic factor (BDNF), a potential therapeutic for Huntington's disease. First, four different manufacturing strategies were investigated with lysozyme as a model substance: either lyophilized protein was mixed with lipid powder, or suspended in organic solution thereof (s/o). Or else, an aqueous protein solution was dispersed by w/o emulsion in organic lipid… CONTINUE READING

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