Towards continuous glucose monitoring: in vivo evaluation of a miniaturized glucose sensor implanted for several days in rat subcutaneous tissue

@article{MoattiSirat1992TowardsCG,
  title={Towards continuous glucose monitoring: in vivo evaluation of a miniaturized glucose sensor implanted for several days in rat subcutaneous tissue},
  author={D. Moatti-Sirat and Fr{\'e}d{\'e}rique Capron and Vincent Poitout and G{\'e}rard Reach and Dilbir S. Bindra and Yanling Zhang and George S. Wilson and Daniel R. Th{\'e}venot},
  journal={Diabetologia},
  year={1992},
  volume={35},
  pages={224-230}
}
A miniaturized amperometric, enzymatic, glucose sensor (outer diameter 0.45 mm) was evaluated after implantation in the subcutaneous tissue of normal rats. A simple experimental procedure was designed for the long-term assessment of the sensor's function which was performed by recording the current during an intraperitoneal glucose load. The sensor was calibrated by accounting for the increase in the current during the concomitant increase in plasma glucose concentration, determined in blood… CONTINUE READING