Towards building a chromosome segregation machine

@article{Bloom2010TowardsBA,
  title={Towards building a chromosome segregation machine},
  author={Kerry S. Bloom and Ajit P. Joglekar},
  journal={Nature},
  year={2010},
  volume={463},
  pages={446-456}
}
All organisms, from bacteria to humans, face the daunting task of replicating, packaging and segregating up to two metres (about 6 × 109 base pairs) of DNA when each cell divides. This task is carried out up to a trillion times during the development of a human from a single fertilized cell. The strategy by which DNA is replicated is now well understood. But when it comes to packaging and segregating a genome, the mechanisms are only beginning to be understood and are often as variable as the… CONTINUE READING