Towards biologically conformal radiation therapy (BCRT): Selective IMRT dose escalation under the guidance of spatial biology distribution.

@article{Yang2005TowardsBC,
  title={Towards biologically conformal radiation therapy (BCRT): Selective IMRT dose escalation under the guidance of spatial biology distribution.},
  author={Yong Yang and Lei Xing},
  journal={Medical physics},
  year={2005},
  volume={32 6Part1},
  pages={1473-1484}
}
It is well known that the spatial biology distribution (e.g., clonogen density, radiosensitivity, tumor proliferation rate, functional importance) in most tumors and sensitive structures is heterogeneous. Recent progress in biological imaging is making the mapping of this distribution increasingly possible. The purpose of this work is to establish a theoretical framework to quantitatively incorporate the spatial biology data into intensity modulated radiation therapy (IMRT) inverse planning. In… CONTINUE READING

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Intensity-modulated whole pelvic radiotherapy in women with gynecologic malignancies.

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