Towards automation of a valuable preclinical cardiac safety pharmacology assay: Evaluation of the effects of cardiac ion channel blockers on cardiac repolarisation in vitro.

Abstract

INTRODUCTION Purkinje fibre repolarisation assays are valuable tools for identifying compounds which affect cardiac ion channels. The throughput of compound testing in this assay is low therefore we designed a novel recording system to improve screening and animal tissue usage efficiencies. METHODS The system was used to evaluate compounds using standard… (More)

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@article{Lightbown2007TowardsAO, title={Towards automation of a valuable preclinical cardiac safety pharmacology assay: Evaluation of the effects of cardiac ion channel blockers on cardiac repolarisation in vitro.}, author={Ian D Lightbown and Mark Johnson and Anne Davis and Joanne L. Leaney and Derek J. Leishman}, journal={Journal of pharmacological and toxicological methods}, year={2007}, volume={56 2}, pages={194-202} }