Towards an understanding of breast cancer etiology.

  title={Towards an understanding of breast cancer etiology.},
  author={H O Adami and L B Signorello and Dimitirios Trichopoulos},
  journal={Seminars in cancer biology},
  volume={8 4},
We present an etiological model for breast cancer in humans, and we examine whether it accommodates the patterns of occurrence of this disease and the associated risk factors. The model has four components: (1) the likelihood of breast cancer occurrence depends on the number of cells at risk; (2) the number of target cells is partially determined early in life, perhaps even in utero; (3) while a pregnancy stimulates the replication of already initiated cells, it conveys long-term protection… CONTINUE READING

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