Towards a unified model of RAF inhibitor resistance.


ATP-competitive RAF inhibitors elicit profound but often temporary antitumor responses in patients with BRAF-mutant melanoma. Analysis of tumor samples collected at the time of disease progression indicates that alterations within the extracellular signal-regulated kinase (ERK) pathway that result in reactivation of ERK signaling are present in most… (More)
DOI: 10.1158/2159-8290.CD-13-0961


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@article{Solit2014TowardsAU, title={Towards a unified model of RAF inhibitor resistance.}, author={David B. Solit and Neal Rosen}, journal={Cancer discovery}, year={2014}, volume={4 1}, pages={27-30} }