Towards a transcriptome definition of microglial cells

  title={Towards a transcriptome definition of microglial cells},
  author={Linda B. Moran and Dawn Duke and Federico E. Turkheimer and Richard B. Banati and Manuel Gr{\"a}ber},
This study provides an expression signature of interferon-gamma (IFN-γ)-activated microglia. Microglia are macrophage precursor cells residing in the brain and spinal cord. The microglial phenotype is highly plastic and changes in response to numerous pathological stimuli. IFN-γ has been established as a strong immunological activator of microglial cells both in vitro and in vivo. Affymetrix RG_U34A microarrays were used to determine the effect of IFN-γ stimulation on migroglia cells isolated… CONTINUE READING
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