Towards a total synthesis of the new anticancer agent mensacarcin: synthesis of the carbocyclic core.

@article{Tietze2004TowardsAT,
  title={Towards a total synthesis of the new anticancer agent mensacarcin: synthesis of the carbocyclic core.},
  author={L. F. Tietze and S. G. Stewart and M. Polomska and Andrea Modi and A. Zeeck},
  journal={Chemistry},
  year={2004},
  volume={10 20},
  pages={
          5233-42
        }
}
  • L. F. Tietze, S. G. Stewart, +2 authors A. Zeeck
  • Published 2004
  • Chemistry, Medicine
  • Chemistry
  • A synthesis of the carbocyclic core associated with the new anticancer agent mensacarcin (1) is reported. The strategy involves the synthesis of several novel highly substituted aromatic compounds, such as 12 and 23. The lithium derivative of 12 readily engages in a nucleophilic addition to benzaldehyde 4 to provide the diphenylcarbinol rac-15. The analogous benzyl ether rac-16 undergoes an intramolecular Heck reaction to provide the required tetrahydroanthracene rac-17, which can be… CONTINUE READING
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