Towards a surrogate system to express human lipid binding TCRs

@article{Wang2019TowardsAS,
  title={Towards a surrogate system to express human lipid binding TCRs},
  author={Rui Wang and Ronja Pscheid and Ashfaq Ghumra and Lea Ling-Yu Kan and Stella Cochrane and Lucy Fairclough and Marcos J. C. Alcocer},
  journal={Biotechnology Letters},
  year={2019},
  volume={41},
  pages={1095 - 1104}
}
Previously we reported that natural nut lipids were necessary for sensitization and that natural killer T cells (NKTs) must play a critical role in the development of food allergic responses. [] Key Result Further, a commercial human Jurkat T cell line containing an inducible secreted luciferase reporter construct was shown to be functional and can be used for a transient expression of human TCRs in a lipid screening program.
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Defining lipids and T cell receptors involved in the intrinsic allergenicity of nut proteins

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