Towards a small animal model for hepatitis C.

  title={Towards a small animal model for hepatitis C.},
  author={Alexander Ploss and Charles M. Rice},
  journal={EMBO reports},
  volume={10 11},
Hepatitis C virus (HCV) causes chronic liver disease and affects an estimated 3% of the world's population. Options for the prevention or therapy of HCV infection are limited; there is no vaccine and the nonspecific, interferon-based treatments now in use are frequently ineffective and have significant side effects. A small-animal model for HCV infection would significantly expedite antiviral compound development and preclinical testing, as well as open new avenues to decipher the mechanisms… CONTINUE READING


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their replication capacity in vivo and in cell culture

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