Towards a robust algorithm to determine topological domains from colocalization data

  title={Towards a robust algorithm to determine topological domains from colocalization data},
  author={Alexander P. Moscalets and Leonid Nazarov and Mikhail V. Tamm},
  journal={arXiv: Biological Physics},
One of the most important tasks in understanding the complex spatial organization of the genome consists in extracting information about this spatial organization, the function and structure of chromatin topological domains from existing experimental data, in particular, from genome colocalization (Hi-C) matrices. Here we present an algorithm allowing to reveal the underlying hierarchical domain structure of a polymer conformation from analyzing the modularity of colocalization matrices. We… 

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